منابع مشابه
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections
Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 pilus adhesin, FimH, demonstrated oral activity in animal models of UTI but were found to have limited compound exposure due to the metabolic instability of the O-glycosidic bond (O-mannosides). Herein, we disclose ...
متن کاملA FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131.
BACKGROUND Escherichia coli O25b:H4-ST131 represents a predominant clone of multidrug-resistant uropathogens currently circulating worldwide in hospitals and the community. Urinary tract infections (UTIs) caused by E. coli ST131 are typically associated with limited treatment options and are often recurrent. METHODS Using established mouse models of acute and chronic UTI, we mapped the pathog...
متن کاملCloning of fimH and fliC and expression of the fusion protein FimH/FliC from Uropathogenic Escherichia coli (UPEC) isolated in Iran
BACKGROUND AND OBJECTIVES Urinary tract infection (UTI) is one of the most common infections in the world. The majority of UTIs are caused by Uropathogenic Escherichia coli (UPEC) strains. FimH and FliC are the most important virulence factors of UPEC. To date, any ideal vaccine against UTI has not been approved for human use and we need to test new targets to develop an ideal vaccine against U...
متن کاملAntibacterial Potentials of Adiantum Species against the UTI Pathogens
The present study was aimed to screen the anti-bacterial properties of medicinally important ferns viz., Adiantum caudatum L., Adiantum latifolium Lam. and Adiantum lunulatum Burm against the selected UTI pathogens. Anti-bacterial study was carried out by disc diffusion method against the pathogens viz., Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus maximum degree of antibac...
متن کاملAllosteric Coupling in FimH
Background: The bacterial adhesin FimH is allosterically regulated. Results: Mutations designed to control the allosteric state of the protein created low or high affinity variants as predicted. Conclusion: Three regulatory regions are strongly coupled together, while the active site is more weakly coupled to those regions. Significance: Allosteric regulation can be used to develop antiadhesive...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2011
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2011.204